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American Society of Microbiology ABMM Sample Questions:

1. A patient with a history of travel to an area endemic for schistosomiasis presents with hematuria. Microscopic examination of a urine sediment reveals a large oval egg with a prominent terminal spine. The MOST likely causative agent is:

A) Schistosoma mansoni
B) Schistosoma mekongi
C) Schistosoma haematobium
D) Schistosoma japonicum

2. A patient develops a severe skin infection after a puncture wound sustained while gardening. Culture of the wound exudate grows a Gram-positive, spore-forming bacillus that is anaerobic and produces a potent neurotoxin causing sustained muscle contraction. The MOST likely organism is:

A) Clostridium perfringens
B) Clostridium botulinum
C) Bacillus anthracis
D) Clostridium tetani

3. A microbiology laboratory is asked to identify the causative agent of a fungal keratitis. Microscopic examination of corneal scrapings reveals broad, aseptate hyphae with right-angle branching. The MOST likely genus is:

A) Aspergillus
B) Candida
C) Fusarium
D) Mucor or Rhizopus

4. The erm gene in Staphylococcus aureus confers resistance to which class(es) of antibiotics via modification of the ribosomal target site?

A) Macrolides, Lincosamides, and Streptogramin B (MLS<sub>B</sub>)
B) Fluoroquinolones
C) Beta-lactams only
D) Aminoglycosides

5. A patient with a history of chronic lung disease develops a severe pneumonia. Bronchoalveolar lavage fluid reveals the presence of numerous cysts containing multiple nuclei, which stain positively with silver stains but poorly with Gram stain. The patient's CD4+ T-cell count is within the normal range. The MOST likely causative organism and the preferred treatment are:

A) Pneumocystis jirovecii; trimethoprim-sulfamethoxazole.
B) Paragonimus westermani; praziquantel.
C) Histoplasma capsulatum; amphotericin B followed by itraconazole.
D) Blastomyces dermatitidis; itraconazole.

Solutions: