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最新的 ASM-ABMM ABMM 免費考試真題:

1. A research laboratory is investigating the mechanisms of antigenic variation in Trypanosoma brucei, the causative agent of African trypanosomiasis. The parasite evades the host immune response by periodically changing its surface coat protein. This process primarily involves:

A) High-frequency point mutations in the gene encoding the variant surface glycoprotein (VSG).
B) RNA interference-mediated silencing of expressed VSG genes followed by activation of a new VSG gene.
C) Segmental gene conversion events involving a large repertoire of silent VSG genes.
D) Recombination between different VSG gene loci on minichromosomes.

2. During the investigation of a foodborne illness outbreak linked to raw sprouts, several bacterial isolates are obtained from patient stool samples and the implicated food source. Which of the following molecular methods would be MOST useful for establishing a definitive link between the clinical isolates and the food isolate?

A) Gram staining and biochemical profiling
B) Antimicrobial susceptibility testing
C) Pulsed-field gel electrophoresis (PFGE)
D) Serotyping based on O and H antigens

3. A laboratory worker sustains a needlestick injury while handling a blood sample known to be positive for Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg). The worker has completed the HBV vaccination series and has a documented anti-HBs titer >10 mIU/mL one month ago. What is the recommended post-exposure prophylaxis?

A) Hepatitis B immune globulin (HBIG) only
B) Hepatitis B vaccine booster dose only
C) Both HBIG and HBV vaccine booster dose
D) No treatment required

4. A research laboratory is investigating the mechanism of action of a novel antiviral compound that inhibits the replication of a specific RNA virus. They find that the compound binds directly to the viral RNA-dependent RNA polymerase, preventing its elongation activity. This mechanism is most similar to that of:

A) Interferon-beta
B) Oseltamivir
C) Acyclovir
D) Ribavirin

5. A patient with a history of recurrent sinusitis and bronchitis is diagnosed with cystic fibrosis. Sputum cultures repeatedly grow a Gram-negative rod that is oxidase-positive and produces a blue-green pigment. This organism's chronic colonization of the respiratory tract in cystic fibrosis patients is primarily due to its ability to:

A) Produce potent exotoxins that damage the ciliated epithelium.
B) Evade phagocytosis by alveolar macrophages through capsule production.
C) Exhibit rapid intracellular replication within respiratory epithelial cells.
D) Form a biofilm that protects it from host defenses and antibiotics.

問題與答案：